The objective of this study was to determine heifer health and growth after transportation and acclimation to a new environment when fed a novel egg yolk antibody to interleukin-10. One hundred sixty recently transported Holstein heifers (13.7 ± 0.8 wk old and 125.9 ± 13.0 kg BW) were randomly allocated to pens of 8 heifers with pen considered the experimental unit. Every 4 pens of 8 heifers was considered a block with a total of 5 blocks in randomized complete block design. Each pen within a block was randomly assigned to 1 of 4 treatments and remained on the study for 70 d. Treatments consisted of 1) a positive control with heifers fed sodium monensin at 160 mg per heifer daily (ION), 2) a negative control without any medicated feed (NEG), 3) heifers fed egg yolks containing an antibody to interleukin-10 derived from chickens immunized against interleukin 10 (aIL-10) (1100 ug of antibody per heifer daily for 2 weeks after arrival), and 4) an egg control with egg yolks obtained from sham-immunized chickens (EC). Average daily gain, frame measures, feed efficiency, DMI, and natural log of coccidial oocysts were analyzed using PROC MIXED a procedure in SAS 9.4. Fecal floats were analyzed with the FREQ procedure for positive or negative for coccidial oocysts using CHI-SQUARE analysis. No differences in intake or growth measures were observed across treatments (P > 0.18) with a mean daily gain of 0.95 kg/d. A difference in feed efficiency across treatments was seen (P = 0.05) with ION having greater efficiency than EC (P < 0.01), and aIL-10 had a tendency to have greater efficient than EC (P = 0.06). Heifers fed ION had reduced incidence and coccidia counts than the other treatments at wk 4 after arrival (P < 0.01), however at wk 8 all treatments had similar incidence and counts (P > 0.26). All heifers were negative for coccidia at arrival with minimal infections until 4 weeks after arrival. Overall, aIL-10 had minimal effects possibly due to lack of coccidia infections during aIL-10 feeding.