The objective of this study was to determine if feed additives in non-medicated milk replacer (MR) and starter could improve health and growth of Holstein calves through 13 wk of age. The experiment was a randomized complete block design with 30 male calves per treatment, purchased when < 3 d old from a commercial farm. Treatments were: control MR and starter with no additives (CON); a commercially available phytogen and yeast extract (Surmount, PMI Nutrition, Arden Hills, MN) in MR and a blend of yeast products and phytogenics (Victant, PMI Nutritional Additives) in starter (CTP); and the same MR with starter (CEP) containing an experimental blend of direct-fed microbials and phytogens (Calf EXP Pak, PMI Nutrition). Intakes of MR, starter, and water were recorded daily. Measurements of BW, body length (BL), withers height (WH), hip height (HH), and hip width (HW) were recorded weekly. Calves were weaned on d 49 and moved from individual hutches to group housing by treatment group on d 56. Calves remained in groups until d 91. Growth and intake data were analyzed using the MIXED procedure and health data were analyzed using GLIMMIX and FREQ procedures in SAS. Intakes of MR and starter did not differ through d 56 (P > 0.17), but group starter intake was greater (P < 0.02) for CTP than CEP or CON. During the pre-weaning period BW was greater (P < 0.04) for CTP, which continued to d 56 and after (P < 0.04). Mean BW at d 91 were 100.9, 112.6, and 107.2 kg for CON, CTP, and CEP. Differences in BW were reflected in similar differences in BL, HW, and HH. The number of times calves were medicated was different among the groups (P < 0.01), with CTP calves being medicated the least (63 times), compared with CON and CEP (144 and 145 times, respectively). Instances of fecal scores > 2 (4-point scale) were lower (P = 0.04) for CTP (366 instances) compared with CON and CEP (463 and 441 instances, respectively). Nasal discharge scores showed a similar pattern among treatments. In conclusion, both feed additive groups showed greater growth than CON, but only CTP improved measures of health.