We evaluated the effects of commercially available saturated fatty acid (SFA) supplements on nutrient digestibility and production responses of lactating dairy cows. The database was formed from 30 peer-reviewed publications in which SFA supplements were fed at ≤3% diet DM. Supplements were classified as mixed SFA (MIX: ≥80% C16:0+C18:0) or palmitic acid-enriched (PALM: ≥80% C16:0) supplements and compared with nonfat supplemented diets used as control. Meta-analysis was performed using PROC MIXED of SAS, including fixed effects of fat source, and random effects of study, and its interaction with treatment. Studies were weighted based on the inverse of the sum of both the within and among study variance. There was no interaction between treatments and experimental design (randomized vs. crossover/Latin square; P > 0.93). Overall, SFA supplementation did not affect DMI (P = 0.68), increased milk (1.36 kg/d, P < 0.01) and fat (0.07 kg/d, P < 0.01) yields, tended to increase protein yield (0.03 kg/d, P = 0.06), increased milk fat content (0.12%, P = 0.01), decreased milk protein content (0.04%, P = 0.03), tended to increase DM digestibility (1.19%, P = 0.07), increased NDF digestibility (3.19%, P < 0.01), and did not affect FA digestibility (P = 0.29). Compared with control, MIX did not affect DMI (P = 0.64), increased milk (1.19 kg/d, P < 0.01) and fat (0.05 kg/d, P = 0.05) yields, did not affect protein yield (P = 0.34) or fat content (P = 0.34), tended to decrease protein content (0.06%, P = 0.06), and had no effect on nutrient digestibility (all P > 0.30). Compared with control, PALM did not affect DMI (P = 0.19), increased milk (1.54 kg/d, P = 0.04) and fat (0.10 kg/d, P < 0.01) yields, tended to increase protein yield (0.04 kg/d, P = 0.09), increased fat content (0.17%; P < 0.01), had no effect on protein content (P = 0.22), and increased DM and NDF digestibility by 1.56% (P = 0.02) and 4.79% (P < 0.01) units, respectively. PALM had no effect on FA digestibility (P = 0.53). Overall, SFA supplementation increased yields of milk and milk fat without affecting DMI, with differences for each SFA supplement type. PALM increased DM and NDF digestibility but MIX did not impact nutrient digestibility.