There is an ethical need to reduce on-farm antibiotic use by implementing disease prevention strategies. Supplementing calves with colostral immunoglobulins (IgGs) post-gut closure (after 24 h of age) is an often discussed, seldom researched approach that could achieve this goal. The study objectives were to evaluate the effects supplementing calves with a concentrated source of whey-based IgG, from birth to d 14 on antibiotic use, morbidity, and mortality. The IgG was from a commercially available colostrum replacer product (Premolac, Zinpro Corp., Eden Prairie, MN; PZ). Upon arrival at the calf raising facility, 1,037 newborn, Holstein calves were randomly assigned to 1 of 3 treatments of added IgG: 1) 0 g (CON), 2) 10 g (CR10; 23 g PZ), or 3) 20 g (CR20; 46 g PZ) per day. Treatments were added to milk replacer diets fed to individually housed calves, 2x/d for 14 d. Antibiotic use, morbidity, and mortality were monitored throughout the study. Weaning started on d 53 and calves were removed from hutches on d 69, on average. Multivariable logistic regression analysis showed that the odds to be treated with antibiotics for diarrhea was 32% less for CR20 calves than for CON calves (P = 0.05). Overall, the incidence of calves treated with antibiotics for diarrhea was reduced from 44.4 to 35.3% (CON and CR20 respectively; P = 0.05). Calves fed CR20 were 48% less likely to be treated with antibiotics, for any reason, compared with CON calves (P < 0.05). Overall antibiotic treatment rates were reduced from 92.4 to 86.2% (CON and CR20 respectively; P < 0.05). Feeding CR10 reduced antibiotic use compared with CON, but this difference was only numerical. Calves fed CON had a 6.6% mortality rate, compared with 2.0% for CR20 calves (P < 0.01). Although numerically lower, mortality in calves fed CR10 was similar to CON (5.4%; P > 0.05). Overall, calves fed CR20 had a 70% lower mortality incidence (P < 0.01) than calves fed CON. These findings indicate, feeding calves at least 20 g of IgG from a PZ for 14 d can reduce antibiotic use and significantly decrease morbidity and mortality incidence.