A cumulative meta-analysis examining the effects of all calcium salts of palm fatty acid distillate (CS) on production responses that includes all study designs is not available. The objective of the current analysis was to examine dry matter intake (DMI), milk yield (MY), and component production in lactating dairy cows supplemented with CS. Data included in the study were extracted from 31 peer-reviewed publications which included 74 treatment means that were supplemented with CS and 65 non-supplemented control (CON) diets. Dietary nutrient concentrations (DM%; range) were 17.4% CP [14 – 23.3%], 32.0% starch [23.4 – 42.2%], and 34.0% NDF [24.8 – 51.7%]. The average feeding amount of CS was 661.7 ± 275.5 g/d. A random-effects model with the random effect of study was chosen to estimate the mean of the sampling distribution of possible effect sizes, and studies were weighted by the inverse of their variance. Weighted mean differences between CS and CON treatments as well as standard errors of the differences between means are reported. Calcium salts decreased DMI (20.04 vs 20.97 ± 0.181 kg/d; P < 0.01), however, NE_L intake did not differ among treatments (36.85 vs 35.98 ± 0.550 Mcal/d; P = 0.11). Milk yield increased (32.61 vs 31.82 ± 0.260 kg/d; P < 0.01) with CS supplementation. Milk fat percentage increased (3.48 vs 3.42 ± 0.023%; P < 0.01), milk protein percentage decreased (3.03 vs 3.12 ± 0.011%; P < 0.01), and milk lactose percentage did not differ (4.99 vs 4.97 ± 0.021%; P = 0.40) with CS supplementation. Yields of milk fat and lactose increased (1.13 vs 1.08 ± 0.012 kg/d; P < 0.01; 1.48 vs 1.38 ± 0.014 kg/d; P < 0.01; respectively), while protein yield was unchanged (1.00 vs 1.01 ± 0.011 kg/d; P = 0.45). Supplementation with CS in lactating cows has mixed effects on production, as evidenced by decreased DMI, milk protein percentage, and milk protein yield and increased MY, milk fat percentage and yield, and milk lactose yield.