One-hundred and nine (2 to 5 d old) individually fed Holstein heifer calves (39.2 ± 0.65 kg) from 3 commercial dairies were randomly assigned to 1 of 4 milk replacer (MR) treatments to evaluate pre- (d 1–42) and post weaning (d 43–56) calf performance and health when supplemented with various additives. The study was conducted between March and June 2016. Treatments included (1) all-milk protein, non-medicated MR 24% CP: 20% Fat fed at 0.34 kg in 2.38 L of water 2× daily from d 1 to d 35 and 1× daily from d 36 to d 42 (CON); (2) CON supplemented with neomycin sulfate and tetracycline (NT) at a rate of 22 mg/kg of body weight for 14 d (MRNT); (3) CON supplemented with 6 g of dried colostrum powder providing 3 g of IgG per feeding for 14 d (MRCP); and (4) CON supplemented with an additive blend of animal plasma, Bio-Mos, microalgae meal (All-G Rich, Schizochytrium limacinum), essential oils (Apex) and multiple direct fed microbial strains including Lactobacillus and Bacillus from d 1–42 (MRAB). Calf starter (18% CP as fed) and water were fed free choice d 1–56. There were no differences in pre weaning gain (d 1–42; P > 0.05) averaging 0.57 kg/d. Post-weaning gains (d 43–56) did not differ and averaged 0.90 kg/d. Overall gain was similar (P > 0.05) and averaged 0.62, 0.68, 0.63 and 0.66 kg/day for CON, MRNT, MRCP, and MRAB, respectively. There was no difference in hip height gain, which averaged 11.4 cm for all treatments. There was no difference in MR solids intake, which averaged 27.7 kg for 42 d. Calf starter intake from d 1- 56 was similar (P > 0.05) for all treatments, averaging 37.1, 40.9, 35.6, and 40.9 kg for CON, MRNT, MRCP, and MRAB, respectively. There were no differences in daily fecal scores, scouring days, or treatment costs. Under conditions of this study, calves fed milk replacers with alternative additives for health and growth can perform similarly to calves fed NT.