Our objective was to evaluate growth, metabolic and rumen profile, and health of calves supplemented with condensed whey solubles (CWS) on starter pellets. Forty-eight 2 d-old calves in huts were used in a 12-wk randomized complete block design study. Calves were blocked by breed (33 Holstein, 15 Brown Swiss), sex (30 female; 18 male), and birth date. Treatments were: 1) control (CON) with no supplement, 2) 40 mL/d CWS (CWSL), and 3) 80 mL/d CWS (CWSH) top-dressed on ad libitum-fed starter pellets. Calves were fed 2.83 L of pasteurized milk 2 × /d during wk 1 to 5, 1 × /d in wk 6, and weaned at d 42. Fecal scores (0 = firm, 3 = watery) and respiratory scores from the sum of rectal temperature, cough, ocular and nasal discharge scores were observed daily. Body weights (BW), frame measures, and jugular blood samples were taken 1 d/wk at 3 h post feeding. Rumen samples were taken wk 8 and 12 via esophageal tubing. Data were analyzed using MIXED procedures of SAS 9.4 with repeated measures. Significance was declared at P < 0.05 and tendencies were 0.05 ≤ P < 0.10. Total DMI (1.53, 1.64, and 1.67 kg/d; SEM = 0.73 for CON, CWSL, and CWSH, respectively) were similar, but had a treatment by time interaction, tending to increase with CWS post-weaning. Average daily gains (0.68, 0.72, 0.75 kg/d; SEM 0.06) were similar, but BW (69.5, 70.8, 73.2 kg; SEM = 1.59), withers heights (82.9, 84.2, and 84.1 cm; SEM = 0.82), and heart girth (92.7, 93.6, 93.8 cm; SEM = 0.66) tended to increase post-weaning with CWS. Other frame measures and BCS were similar. Health scores were not different, but post-weaning fecal scores (0.11, 0.09, and 0.13; SEM = 0.03) were firmer (P < 0.01) for CWSL. Rumen VFA profiles, PUN (18.2, 17.7, and 17.6 mg/dL; SEM = 0.63), glucose (96.4, 100.5, and 104.8 mg/dL; SEM = 1.63), cholesterol (47.1, 49.3, and 51.5 mg/dL; SEM = 2.34), triglycerides (15.8, 15.8, and 16.4 mg/dL; SEM = 1.17) and BHB (35.4, 35.1, and 36.0 mg/dL; SEM = 0.63) were similar. Supplementing CWS improved calf post-weaning intakes, growth, and fecal scores with maintained rumen VFA, and metabolic profile.