The objective of this study was to compare the impact of milk consumption, health incidences, and growth between Holstein and Angus × Holstein F₁ calves fed through automated calf feeders. Daily milk consumption, serum total protein (STP), pneumonia and scours incidences, birth weights and weaning weights were recorded on a commercial dairy farm from October 1, 2017 to January 30, 2019. Calves (n = 4,185; Holstein n = 2,912, Angus × Holstein F1 n = 1,273) were fed pasteurized waste milk with a 30% protein, 5% fat milk enhancer added at 20 g/L of milk through a Förster-Technik automated calf feeding system (pens = 16; feeders per pen = 2) for an average of 68 d. STP was taken between 1 and 7 d after birth (6.8 ± 0.69 g/dL, mean ± SD). Daily BW was estimated for individual animals using Legendre polynomials to best model growth data. The effects of feeder, days on feeder, incidences of pneumonia and scours, STP, breed and sex were evaluated using a multiple regression model to predict body weight and total milk consumption. When predicting total milk consumption, 4 variables were highly significant: feeder, pneumonia incidences, STP, and days on feeder (all P < 0.0001; R² = 0.56). For each additional day on feeder, total milk consumption increased by 5.7 L and calves diagnosed with pneumonia had reduced total milk consumption (0 cases = 484, 1 case = 468, 2 cases = 458, 3 cases = 440 and ≥ 4 cases = 420 L). Six variables contributed to predicted body weight at 60 d: feeder, sex, total consumption of milk, and pneumonia incidences (all P < 0.0001), breed (P < 0.04), and STP (P = 0.10; entire model R² = 0.38). Calves were 7.0 kg less at 60 d if they were treated for pneumonia 3 times compared with calves with no treatment for pneumonia during the pre-weaning period. Holstein calves were 1.4 kg larger at 60 d than Angus × Holstein F₁ calves and males were 4.5 kg larger than females. Pneumonia incidences negatively affected both milk consumption and predicted BW at 60 d. Overall, there were no breed differences in milk consumption between Holstein and Angus × Holstein F₁ calves and Holsteins had a slight advantage in predicted BW at 60 d.