Our objective was to determine the effects of supplementation of condensed whey solubles (CWS) on growth performance and health of dairy calves when fed with starter grain mix in a commercial dairy. Calves (2 d old; 350 Crosses, 124 Jersey, 42 Holstein) housed in individual hutches were used in a 12 wk completely randomized design study. Treatments were 1) control (CON) with no supplements, 2) 42 g/d of CWS (CWSL), and 3) 84 g/d of CWS (CWSH). During first 2 wk CWS was fed with milk replacer (MR) and during wk 3–12 CWS was mixed with starter (CP 22%). Calves were fed 1.89 L of MR from wk 1 to 2 and 2.83 L from wk 2 to 8.5, 2 × /d. From wk 8.5 to 11 calves fed 1.89 L MR, 1 × /d then weaned. Starter and water were fed ad libitum. Individual intakes of milk and starter were measured daily. Fecal (0 = firm, 3 = watery) and respiratory scores were recorded daily. Body weights (BW), frame growth and jugular blood samples were taken 1 d at wk 0, 8, and 12 at 3 h after morning feeding of 50 calves per treatment. Data were analyzed using MIXED procedures of SAS 9.4 with repeated measures. Significance was declared at P < 0.05 and tendency was 0.05 ≤ P < 0.10. Starter DMI tended to be greater (P = 0.09) in CWSL (573, 631 and 543 g/d; SEM = 31.5 for CON, CWSL and CWSH, respectively). Total DMI tended to be greatest (P = 0.08) in CON (1242, 1239, and 1143 g/d; SEM = 37.5). Starch intakes (213, 230 and 187 g/d; SEM = 11.3) were greater in CWSL. Sugar intakes (251, 290, and 297 g/d; SEM = 8) were greater in CWSL and CWSH. Calf BW (70, 75, and 69 kg; SEM = 1.4) and ADG (0.99, 1.06 and 0.97 kg/d; SEM = 0.02) were greater in CWSL. Glucose (101, 95, and 97 mg/dL; SEM = 1.54) was greater in CON. Β-hydroxybutyrate (BHB; 44, 52, and 46 mg/dL; SEM = 1.93) was greater in CWSL. Less diarrhea incidences (0.17, 0.11, and 0.18%) were observed in CWSL. The gain: feed, withers height, hip width, plasma urea nitrogen and fecal scores were not different among the treatments. Supplementing CWSL improved starter intake, BW, BHB, fecal consistency, health with maintained frame growth.