Systemic inflammation and sub-optimal feed intake are common in dairy cows in the transition to lactation, and both conditions are associated with greater risk for removal from the herd and less productivity. No compelling mechanistic link has tied postpartum inflammation to suppression of feed intake. Recent findings in rodents demonstrated that an acute phase protein, α-1-acid glycoprotein (AGP), could provide this link by acting as a leptin receptor agonist. To determine the feed intake dose response of sheep to central AGP administration, nonlactating, non-pregnant, adult (≥1 yr of age) mixed breed black face ewes (n = 4) weighing 79.0 ± 5.0 (SD) kg were ovariectomized and surgically implanted with a cannula into a lateral ventricle of the brain. Ewes were kept indoors in individual pens with an environment consisting of a 12-h light/dark photoperiod and approximately 22–24°C. Ewes were fed a diet calculated to meet 100% of daily maintenance requirements and had ad libitum water. Ewes received 1 of 4 treatments [0 (control), 12 (low), 60 (medium), or 300 (high) µg/kg BW AGP (AGP from bovine plasma; Sigma Aldrich Co. Saint Louis, MO)] administered in 500 µL of sterile, nonpyrogenic, isotonic, 0.9% sodium chloride into the lateral ventricle. Sheep were allowed ad libitum access to feed and intake was determined at −72, −48, −24, 0, 2, 4, 6, 8, 12, 24, 36, and 48 h relative to treatment. The study was repeated until all sheep received all treatments with a 10-d washout period between treatments. Data were analyzed using procedures for repeated measures with JMP software (version 10.0.0; SAS Inst. Inc., Cary, NC) and tested for effects of replication, treatment, time, and treatment × time interaction. There was an effect of time (P < 0.0001) and no effect of treatment (P = 0.31), replication (P = 0.45) or treatment × time interaction (P = 0.84) on feed intake. These results indicate central AGP administration may not affect feed intake in sheep or concentrations of AGP reached during systemic inflammation, that may affect feed intake, were not achieved in our model.