Parturition is a very dynamic period with a significant change in the physiology and immunology of goats. Periparturient immunosuppression can hinder the ability of goats to thwart infectious diseases. Galectins constitute an evolutionarily conserved family of β-galactoside-binding proteins that are secreted. They are involved in the regulation of homeostasis, innate and adaptive immune responses to infectious challenge. The objective of this study was to determine the secretion of galectins in goat blood during the periparturient period. Five BoerXSpanish goats (average body weight of 156kg and body condition score of 4) from the North Carolina Agricultural and Technical State University Small Ruminant Research Unit were used. Blood samples were collected from the jugular vein at 14 and 7 d before and 7 and 14 d after parturition. Plasma was collected from whole blood in tubes containing EDTA. Total plasma protein concentration was determined using the BCA assay (Thermo Scientific Pierce, Rockford, IL). The secretion of galectins-1, -3, and -9 was detected using goat specific enzyme-linked Immunosorbent assays (ABclonal Biotechnology, Woburn, MA). Data were analyzed using PROC GLM model in SAS 9.4 version (P < 0.05). There was no significant difference in total plasma protein concentration (P > 0.05) during the periparturient period. The average concentration of galectins-1, -3, and -9 was 150, 14, and 3 ng/µL of goat plasma respectively. A postpartum decrease in galectin-1 and an increase of galectins-3 and -9 was observed (P < 0.05). Our results indicate that galectins-1, -3, and -9 are secreted in goat blood. The difference in the pattern of secretion may indicate distinct roles in homeostasis during the periparturient period in goats and needs further study.