Abstract #247

# 247
Cow-level responses to two commercial dry cow mastitis preparations.
E. Cox*1, T. Bilby1, S. Kieser2, B. Petersen3, J. Laporta4, R. Chebel4,5, 1Merck Animal Health, De Soto, KS, 2Dairy Vet Services, Sunnyside, WA, 3Sunrise Veterinary Services, Dalhart, TX, 4Department of Animal Sciences, University of Florida, Gainesville, FL, 5Department of Large Animal Clinical Sciences, University of Florida, Gainesville, FL.

Objectives of this experiment were to compare the efficacy of 2 intramammary (IM) antibiotic formulations in reducing the incidence of IM infections (IMI) during the dry period at the cow-level. Secondary objectives of this experiment were to evaluate the cure of IMI during the dry period at the cow-level and the performance of cows treated with different antibiotic formulations. Cows from 2 herds were used in this experiment. At dry-off, cows were randomly assigned to the ORB (n = 1,310; benzathine cloxacillin; Orbenin-DC, Merck Animal Health, Madison, NJ) and the SPC (n = 1,354; ceftiofur hydrochloride; Spectramast LC, Zoetis, Parsippany-Troy Hills, NJ) treatments. Composite milk samples were collected at dry-off and at parturition and were submitted for microbiology laboratorial analysis. Data were analyzed using SAS. The likelihood of IMI at dry-off and at parturition, the likelihood of a new IMI during the dry period, the likelihood of IMI cure during the dry period, the likelihood of a clinical case of mastitis in the first 100 DIM, and the likelihood of pregnancy after the first 2 postpartum inseminations were analyzed by logistic regression using PROC GLIMMIX. Milk yield, milk composition, and somatic cell count (SCC) were analyzed by ANOVA for repeated measures using PROC MIXED. Dairy was used as the random effect. SPC treatment was used as reference. There was no (P = 0.24) difference between treatments regarding the prevalence of IMI at dry-off (OR = 1.11, 95%CI = 0.94, 1.31). There was no effect of treatment on the likelihood of new IMI during the dry period (OR = 0.91, 95%CI = 0.76, 1.09; P = 0.32), of cure of IMI during the dry period (OR = 0.99, 95%CI = 0.77, 1.28; P = 0.93), of IMI at calving (OR = 0.96, 95%CI = 0.80, 1.15; P = 0.67), and clinical mastitis up to 100 DIM (OR = 0.85, 95%CI = 0.61, 1.17; P = 0.32). Fat corrected milk yield (ORB = 44.1 ± 0.2 vs. SPC = 44.2 ± 0.2 kg/d; P = 0.21) and linear SCC (ORB = 2.02 ± 0.03 vs. SPC = 2.07 ± 0.03; P = 0.85) in the first 100 DIM were not different between treatments. Similarly, treatment did not (P = 0.81) affect likelihood of pregnancy after the first 2 postpartum inseminations (OR = 0.98, 95%CI = 0.83,1.16). No differences were observed between ORB and SPC in regards to the aforementioned outcomes.

Key Words: dry cow preparations, intramammary infection