The objective was to determine relationships between protein and energy consumed from milk replacer and starter and calf growth for Holstein dairy calves. Data were collected from 4,534 Holstein animals from birth year of 2004 through 2014. Calves were received from 3 commercial dairy farms and assigned to 45 different calf research trials at the University of Minnesota Southern Research and Outreach Center from 3 to 195 d. Calves were returned to their farms upon completion of the trial. Most calves were fed a 20% CP and a 20% fat milk replacer at a rate of 0.57 kg/calf per day. Milk replacer ME, starter ME, milk replacer protein intake, and starter intake consumed from 0 to 8 weeks were (mean ± SD): 102.7 ± 13.2 Mcal/kg, 151.0 ± 42.2 Mcal/kg, 4.8 ± 1.0 kg, and 9.5 ± 2.7 kg, respectively. Separate mixed model analysis were conducted with SAS to determine the effect of actual ME consumed from both milk replacer and starter and actual protein consumed from both ME and starter and average daily gain of the calves. Year of birth, season of birth and 8-week ADG class (<0.23, 0.23–0.34, 0.34–0.45, 0.45–0.57, 0.57–0.68, 0.68–0.79, > 0.79 kg/d) were included in the model with trial and herd as a random effect. Calves that had greater intake of protein during the first 8 weeks of life resulted in greater growth (P < 0.01; Table 1). Table 1. Least square means of ADG class and MR and starter ME (Mcal/kg DM) and protein (kg of DM) consumed 0-8 weeks (n=4534 cows)

Variable	P-value	Average daily gain class (kg/d)
		<0.23	0.23–0.34	0.34–0.45	0.45–0.57	0.57–0.68	0.68–0.79	>0.79
MR ME	<0.001	110.7	108.0	102.5	101.4	101.9	102.2	105.0
Starter ME	<0.001	36.8	52.7	84.1	115.8	143.9	172.7	207.0
MR Protein	<0.001	5.3	5.0	4.7	4.7	4.7	4.7	4.9
Starter Protein	<0.001	2.3	3.3	5.3	7.3	9.0	10.8	13.0