The objective of this study was to determine the growth, feed intake, and feed efficiency of pre-bred dairy heifers with different predicted genomic residual feed intake (RFI) as a lactating cow, and offered diets with different energy levels. Pre-bred Holstein heifers (128, ages 4–9 mo) were blocked by weight (high, 286 kg; medium-high, 241 kg; medium-low, 205 kg; and low, 168 kg) with 32 heifers per block. Heifers in each weight block were sorted by RFI to obtain 2 pens of high (HiRFI) and 2 pens of low RFI (LoRFI) for each block with 8 heifers per pen. Heifers with LoRFI are expected to have greater feed efficiency than HiRFI heifers. Dietary treatments were a high-energy diet (HiE; 66.6% TDN, 14.0% CP, and 36.3% NDF, DM basis) and low energy diet (LoE; 63.8% TDN, 13.5% CP, and 41.2% NDF, DM basis). Each pen of heifers was randomly assigned to treatments to obtain a 2x2 factorial arrangement (2 RFI levels and 2 diet energy levels). Diets were offered in a 120 d trial. Statistical analyses were performed using a MIXED procedure in SAS 9.4 with pen as experimental unit. Dry matter intake was not affected by diet (7.38 vs. 7.83 kg DM for HiE and LoE, respectively; P = 0.14), or by RFI (7.40 vs. 7.81 kg DM for HiRFI and LoRFI, respectively; P = 0.17) or their interaction (P = 0.66). Daily gain (ADG) was affected by diet with heifers fed HiE having greater ADG than heifers fed LoE (1.14 vs. 0.97 kg/d; P < 0.01). Also, RFI affected ADG with LoRFI heifers having greater ADG than HiRFI (1.09 vs. 1.02 kg/d; P = 0.03), with the interaction of RFI and diet not significant (P > 0.10). Feed efficiency was improved for heifers fed the HiE diet (6.44 vs. 8.02 kg DMI/kg gain for HiE and LoE, respectively; P < 0.01), but was not affected by RFI (P = 0.48) or the interaction of RFI and diet (P = 0.62). Overall, feed efficiency of pre-breeding heifers was not dependent on genomic RFI. Heifers with LoRFI had greater ADG but this was likely due to a numerical increase in intake. Feed efficiency of heifers was reduced when heifers were fed the LoE diet, but resulted in more optimal ADG than feeding a higher energy diet ad-libitum.