During peripartum, dairy goats show severe modifications of metabolism and immune system. In this period the molecules donor of methyl groups can aid liver metabolism and immune system responses, but the role of these molecules is debated. The aim of the study was to check the effects of supplementation of 10 g of rumen-protected choline (Ruprocol, Vetagro, Reggio Emilia, Italy) (COL) alone or associated with 10 g of rumen-protected methionine (Timet, Vetagro) (MC) administered in the last 7 weeks of pregnancy, on Alpine goats metabolism. Met rate was calculated to decrease the Lys:Met ratio from 3.2:1 in COL to 2.1:1 in MC. The experiment was conducted on 33 pregnant goats (16 in COL and 17 in MC) and supplements were included in the concentrate (350 g/d). Diets were completed with straw ad libitum and substituted with hay few days before kidding. Blood samples were collected weekly 6 weeks before the expected day of parturition until 10 d from kidding (DFK). Goats were milked twice a day and milk samples were collected on d 7, 14, 28 before kidding. The MC group respect to COL did not show differences at metabolic level as glucose, NEFA, BHBA, cholesterol and urea concentration and pattern were similar between groups. Conversely after kidding, MC vs. COL showed a greater increase of plasma myeloperoxidase at d 3 before kidding (533 vs. 500 U/L, P < 0.1), a lower increase of haptoglobin (0.43 vs. 0.77 g/L, P < 0.05) and a higher Zn concentration (8.94 vs. 7.76 mmol/L, P < 0.05). Altogether, these changes suggest a lower involvement of liver in the acute phase response. Indeed, liver functionality resulted better in MC as confirmed by the lower increase of bilirubin at d 3 (0.89 vs 1.58 mmol/L, P < 0.05) and GOT at d 10 (157 vs. 194 U/L, P < 0.05) before kidding. These results suggest that the addition of protected Met to the diet of goats during dry period improves the immune system responsiveness which constrains inflammatory events and in turn ameliorates the liver activity. These better conditions justify the lower mastitis incidence observed during first 28 d before kidding and the lower frequency of goats with SCC higher than 1000 × 10³ cells/mL (54% vs. 18% in COL and MC respectively).