Nili-Ravi buffalo is the most valuable dairy animal in Pakistan. It is well known as black gold of Pakistan. Production efficiency of the breed is compromised due to its reproductive failure most of the time. This will lead to prolong calving interval which enhances input cost of farmer. To overwhelm the low reproductive competence, the objective of this study was to manage the reproduction by using Dalmavital (antioxidant) in CIDR synchronized protocol to increase pregnancy rate. For this purpose, 86 animals with healthy reproductive tract and good body conditions of mixed parity were recruited into 2 groups; (G1): CIDR, G2: CIDR+Dalmavital as control and treatment respectively. CIDR were placed at d 0 and removed at d 7 while PGF2α was injected at d 6. GnRH was injected 36 h after CIDR removal. Dalmavital was injected at CIDR insertion in G2. AI was performed at standing estrus, morning and evening at intervals of 12 and 24 h after GnRH injection. Pregnancy was monitored via ultrasonography at d 30. Data collected was analyzed through Chi-Square and Binary logistic regression model. Results revealed that Estrous intensity was significantly (P < 0.05) higher in CIDR-D than CIDR group. Pregnancy rates in CIDR and CIDR-D had no noteworthy difference (P > 0.05). There was no statistically difference when comparison was made parity wise in CIDR and CIDR-D groups. However, overall there were 57.33% pregnancy rates in CIDR-D as compared CIDR which were 51.5%. Pregnancy rates were improved in fourth and fifth parities (older) as compared with first, second and third parities. It is concluded that Dalmavital has positive effect on estrous intensity but has narrow role in pregnancy rate. However in aged animals pregnancy rates were improved. That may be due to antioxidant nature of Dalmavital which neutralize reactive oxygen species (ROS).